Identification of chemicals of emerging concern in urine of Flemish adolescents using a new suspect screening workflow for LC-QTOF-MS was written by Caballero-Casero, Noelia;Castro, Gabriela;Bastiaensen, Michiel;Gys, Celine;van Larebeke, Nik;Schoeters, Greet;Covaci, Adrian. And the article was included in Chemosphere in 2021.Quality Control of Dimethyl decanedioate This article mentions the following:
An essential step in human biomonitoring or mol. epidemiol. programs is to estimate human exposure to environmental chems. Despite significant progress in the capabilities of anal. methods, the number of pollutants and their metabolites keeps increasing continuously. Some of these relatively unknown chems. of emerging concern (CECs) may pose significant health risks to humans and biota, but remain virtually undetected in traditional HBM-studies. Non-target and suspect screening techniques based on high-resolution mass spectrometry (HRMS) perform the detection and identification of compounds without any a priori compound selection or chem. information and provide a more holistic overview of human exposure. In this study, 50 urine samples (25 female and 25 male) from a larger cohort of the Flemish Environment and Health Study (FLEHS IV, 2016-2020) have been submitted to suspect screening anal., with the aim of detecting and identifying new CECs. For this purpose, an anal. method has been developed, optimized and evaluated in terms of anal. performance. Satisfactory results were obtained in terms of reproducibility, sensitivity and quality control. Data-mining was performed through the combination of two different workflows. The use of two complementary workflows enhanced the number of identified compounds As a result, 45 CECs have been identified with a level of confidence ranged between 3 and 1. Most of the identified compounds were metabolisation products, many of which were currently not included in the targeted measurements of FLEHS IV. The identified chems. and metabolites could be used as candidate biomarkers of exposure in future studies. Overall, the newly developed suspect screening workflow of this pilot study provided complementary and promising results for future HBM-programs. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Quality Control of Dimethyl decanedioate).
Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of Dimethyl decanedioate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics