Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases was written by Annunziato, Giannamaria;Giovati, Laura;Angeli, Andrea;Pavone, Marialaura;Del Prete, Sonia;Pieroni, Marco;Capasso, Clemente;Bruno, Agostino;Conti, Stefania;Magliani, Walter;Supuran, Claudiu T.;Costantino, Gabriele. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2018.Computed Properties of C7H8N2O2 This article mentions the following:
Infections caused by pathogens resistant to the available antimicrobial treatments represent nowadays a threat to global public health. Recently, it has been demonstrated that carbonic anhydrases (CAs) are essential for the growth of many pathogens and their inhibition leads to growth defects. Principal drawbacks in using CA inhibitors (CAIs) as antimicrobial agents are the side effects due to the lack of selectivity toward human CA isoforms. Herein we report a new class of CAIs, which preferentially interacts with microbial CA active sites over the human ones. The mechanism of action of these inhibitors was investigated against an important fungal pathogen, Cryptococcus neoformans, revealing that they are also able to inhibit CA in microbial cells growing in vitro. At our best knowledge, this is the first report on newly designed synthetic compounds selectively targeting β-CAs and provides a proof of concept of microbial CAs suitability as an antimicrobial drug target. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Computed Properties of C7H8N2O2).
Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C7H8N2O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics