Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors was written by Ahn, Jin Hee;Kim, Jin Ah;Kim, Hye-Min;Kwon, Hyuk-Man;Huh, Sun-Chul;Rhee, Sang Dal;Kim, Kwang Rok;Yang, Sung-Don;Park, Sung-Dae;Lee, Jae Mok;Kim, Sung Soo;Cheon, Hyae Gyeong. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.HPLC of Formula: 16413-26-6 This article mentions the following:
A new series of pyrazolidine derivatives was synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV). The most active compound (I) in this series, exhibited IC50 value of 1.56 μM and ED50 value of 80 mg/kg (in vivo DP-IV inhibition; po). In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6HPLC of Formula: 16413-26-6).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.HPLC of Formula: 16413-26-6
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics