Vaton-Chanvrier, L. published the artcileChiral recognition of binaphthyl derivatives: a chiral recognition model on the basis of chromatography, spectroscopy, and molecular mechanistic calculations for the enantioseparation of 1,1′-binaphthyl derivatives on cholic acid-bonded stationary phases, Recommanded Product: (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), the publication is Chirality (2001), 13(10), 668-674, database is CAplus and MEDLINE.
In an effort to elucidate the mechanism of chiral discrimination of cholic acid-based stationary phases, the enantiomeric recognition ability of six chiral stationary phases (CSPs), prepared from differently substituted cholic acid derivatives, was evaluated in normal phase HPLC with 1,1′-binaphthyl compounds The influence of structural variations of analytes on retention and enantioselectivity was studied. Particularly high values of enantioselectivity were observed for the binaphthol enantiomers on a CSP prepared from the allyl 7α,12α-dihydroxy-3α-phenylcarbamoyloxy-5β-cholan-24-oate. The complexes of this chiral selector with both enantiomers of binaphthol were studied as models for the interactions responsible for the enantioseparation with the cholic acid-based stationary phases. The 1:1 stoichiometry of the complex in solution was determined by UV titration The chiral selector dissolved in chloroform exhibited a chiral discrimination for the binaphthol in 1H and 13C NMR spectroscopies. Some aromatic proton and carbon resonances of binaphthol were clearly separated into a pair of peaks due to enantiomers in the presence of the chiral selector. Also, from mol. mechanics calculation, a chiral discrimination model is proposed which nicely explains the relevant chromatog. behavior of the 1,1′-binaphthyl derivatives
Chirality published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C9H7N5O, Recommanded Product: (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate).
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