Suhrkamp, Ina published the artcileOral Dimethyl Fumarate Targets HCA2-Expressing Skin Cells in the Imiquimod Mouse Model, SDS of cas: 624-49-7, the publication is Journal of Investigative Dermatology (2022), 142(9), 2547-2550.e5, database is CAplus and MEDLINE.
Fumarates (fumaric acid esters, FAEs) are orally administered systemic agents used for the treatment of psoriasis and multiple sclerosis. DMF therapy typically improves skin inflammation within the first 3 mo of treatment. The aim of this study was to evaluate pharmacokinetic parameters of fumaric acid esters (FAE) in psoriasis patients for the first time. Flow cytometry was used to assess T-cell and neutrophil frequencies, apoptosis and activation phenotype. Our results reveal a novel in vivo effect of DMF therapy on pro-inflammatory neutrophils that likely contributes to this treatments antipsoriatic efficacy.
Journal of Investigative Dermatology published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C15H14O3, SDS of cas: 624-49-7.
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https://en.wikipedia.org/wiki/Ester,
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