Popovtzer, Rachela published the artcileElectrochemical lab on a chip for high-throughput analysis of anticancer drugs efficiency, HPLC of Formula: 122110-53-6, the publication is Nanomedicine (New York, NY, United States) (2008), 4(2), 121-126, database is CAplus and MEDLINE.
We describe a new method for rapid, sensitive, and high-throughput detection of colon cancer cells’ response to differentiation therapy, using a novel electrochem. lab-on-a-chip system. Differentiation-inducing agents such as butyric acid and its derivatives were introduced to miniature colon cancer samples within the nanovolume chip chambers. The efficacy of each of the differentiation-inducing agents was evaluated by electrochem. detection of the cellular enzymic activity level, whereas reappearance of normal enzymic activity denotes effective therapy. The results demonstrate the ability to evaluate simultaneously multiplex drug effects on miniature tumor samples (∼15 cells) rapidly (5 min) and sensitively, with quant. correlation between cancer cells’ number and the induced current. The use of miniature anal. devices is of special interest in clin. relevant samples, in that it requires less tissue for diagnosis, and enables high-throughput anal. and comparison of various drug effects on one small tumor sample, while maintaining uniform biol. and environmental conditions.
Nanomedicine (New York, NY, United States) published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, HPLC of Formula: 122110-53-6.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics