Stachulski, Andrew V. published the artcileSynthesis, antiviral activity, preliminary pharmacokinetics and structural parameters of thiazolide amine salts, Name: 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, the main research area is thiazolide amine salt xray crystal structure antiviral activity pharmacokinetics; amine salts; antiviral; pharmacokinetics; thiazolides; x-ray structure.
The thiazolides, typified by nitazoxanide, are an important class of anti-infective agents. A significant problem with nitazoxanide and its active circulating metabolite tizoxanide is their poor solubility We report the preparation and evaluation of a series of amine salts of tizoxanide and the corresponding 5-Cl thiazolide. These salts demonstrated improved aqueous solubility and absorption, as shown by physicochem. and in vivo measurements. They combine antiviral activity against influenza A virus with excellent cell safety indexes. We also report the x-ray crystal structural data of the ethanolamine salt. The ethanol salt of thiazolide retains the activity of the parent together with an improved cell safety index, making it a good candidate for further evaluation.
Future Medicinal Chemistry published new progress about Absorption. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Name: 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate.
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