Kelleni, Mina T. published the artcileNSAIDs and Kelleni′s protocol as potential early COVID-19 treatment game changer: could it be the final countdown, SDS of cas: 55981-09-4, the main research area is review asprin triggered lipoxin resolvin benefit; Apoptosis; Aspirin; Azithromycin; COVID-19; Caspases; Endoplasmic reticulum stress; Kelleni’s protocol; NSAIDs; Nitazoxanide; SARS-CoV-2.
A review on previously published several papers illustrating numerous immunomodulatory and anti-inflammatory potential benefits when we repurposed safe, generic non-steroidal anti-inflammatory drugs (NSAIDs)/nitazoxanide/azithromycin (Kellenis protocol), to early manage our COVID-19 pediatric, adult, and pregnant patients. In this manuscript, we discuss some recently published meta-anal. and clin. studies supporting our practice and discuss a mol. study that might be interpreted as an academic proof that our protocol might also prevent SARS-CoV-2 replication. Moreover, after aspirin has been suggested to be independently associated with reduced risk of mech. ventilation, ICU admission and in-hospital mortality of COVID-19, we claim that the mol. interpretation of the results that led to this suggestion was not scientifically accurate, and we provide our academic interpretation confirming that low-dose aspirin is least likely to improve COVID-19 mortality through anticoagulation as was suggested. Furthermore, we describe other potential benefits related to aspirin-triggered lipoxins and resolvins while illustrating how NSAIDs interfere with COX-1, COX-2, SARS-CoV-2/ SARS-CoV-2 ORF protein-dependent activation of caspases and their subsequent mitochondrial dysfunction, endoplasmic reticulum stress, apoptosis and necroptosis which were associated with COVID-19 complications. Similarly, NSAIDs are known caspase inhibitors and thus they might independently inhibit other caspase-related COVID-19-associated downstream pathol. signaling mechanisms. Finally, we postulated that CARD-14, a caspase recruitment domain-containing protein, polymorphisms might play a role in the development of severe and critical COVID-19 and confirmed our old call to early adopt NSAIDs, as an integral part of Kellenis protocol, as of choice in its management aiming to end this pandemic.
Inflammopharmacology published new progress about Apoptosis. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, SDS of cas: 55981-09-4.
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