Zhang, Yuan-Yuan published the artcileDesign, Synthesis, and Biological Activity of Novel Diazabicyclo Derivatives as Safeners, HPLC of Formula: 539-88-8, the main research area is diazabicyclo derivative herbicide safener corn glutathione transferase; N-substituted diazabicyclo; fragment splicing; herbicide safener; intermediate derivatization approach; microwave-assistant synthesis.
Herbicide safeners selectively protect crops from herbicide damage without reducing the herbicidal efficiency on target weed species. The title compounds were designed by intermediate derivatization approach and fragment splicing in order to exploit novel potential safeners. A total of thirty-one novel diazabicyclo derivatives were synthesized by microwave-assistant method using isoxazole-4-carbonyl chloride and diazabicyclo derivatives All synthetic compounds were confirmed by IR, 1H NMR, 13C NMR, HRMS. The bioassay results demonstrated that most of the title compounds could reduce the nicosulfuron phytotoxicity on maize. The glutathione-S-transferase (GST) activity in vivo was assayed and compound 4 (S15) revealed an inspiring safener activity comparable to commercialized safeners isoxadifen-Et and BAS-145138. The mol. docking model exhibited that the competition at the active sites of target enzymes between compound (I) and nicosulfuron was investigated with respect to herbicide detoxification. The current work not only provided a powerful supplement to the intermediate derivatization approach and fragment splicing in design pesticide bioactive mols., but also assisted safener development and optimization.
Journal of Agricultural and Food Chemistry published new progress about Corn. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, HPLC of Formula: 539-88-8.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics