Yaqoob, Urwa published the artcileEfficacy of first dose of nitazoxanide in management of rotavirus diarrhea in children, Application of 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, the main research area is nitazoxanide child rotavirus diarrhea.
Rotavirus is a leading cause of morbidity and mortality in children younger than 5 years. This study was planned to record mean duration of rotavirus diarrhea in children after administration of first dose of nitazoxanide as this drug is cost effective but no local data is available evaluating mean duration of diarrhea after first dose of Nitazoxanide in children with rota virus, while the previous studies were conducted on smaller sample size. To determine the mean duration of rotavirus diarrhea in children after administration of first dose of Nitazoxanide. Descriptive Case study. The calculated sample size is 175, with d = 1, 95% confidence level taking expected mean duration of diarrhea after first dose of administration of Nitazoxanide i.e. 31.0+6.87 h. The study was conducted in Department of Pediatric Medicine, Children Hospital, Faisalabad. Duration of study: Six month from the date of approval of synopsis from board of study (July 2019 to Dec 2019). All 175 patients fulfilling the inclusion/exclusion criteria were enrolled in the study. An informed consent to include their data with the assurance of confidentiality was obtained from their parents. All study cases were administered by the nursing staff as (200 mg nitazoxanide) twice a day for 3 days in patients 4-5 years of age, (100 mg nitazoxanide) twice a day in patients 12-47 mo of age, and (7.5 mg/kg nitazoxanide) twice a day in patients younger than 12 mo. In addition to the study education, all patients were receiving routine care including fluid replacement therapy and nutritional and metabolic management of diarrhoea. The nursing staff followed the children for every 12 h till the normal formed stools. All this information was recorded on a pre-designed proforma. Duration of diarrhea was recorded as per operational definitions. In our study, out of 175 cases, 58.86%(n = 103) were between 2-36 mo of age while 41.14%(n = 72) were between 37-60 mo of age, mean+sd was calculated as 35.06+13.34 mo, 44%(n = 77) were male and 56%(n = 98) were females, mean duration of rotavirus diarrhea in children after administration of first dose of Nitazoxanide was recorded as 32.85+2.32 h. We concluded that the mean duration of rotavirus diarrhea in children after administration of first dose of Nitazoxanide is not more than 1.5 days and it is suitable in our population for the management of rotavirus diarrhea.
Indo American Journal of Pharmaceutical Sciences published new progress about Child. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Application of 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate.
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