Valentini, Francesca published the artcileA stoichiometric solvent-free protocol for acetylation reactions, Formula: C9H10O2, the main research area is acetylation reaction stoichiometric solvent free protocol; acetic anhydride; acetylation; alcohols; isopropenyl acetate; phenols; sustainability; thiols; thymol.
Considering the remarkable relevance of acetylated derivatives of phenols, alcs., and aryl and alkyl thiols in different areas of biol., as well as in synthetic organic chem., a sustainable solvent-free approach to perform acetylation reactions is proposed here. Acetylation reactions are classically performed using excess of acetic anhydride (Ac2O) in solvent-free conditions or by eventually working with stoichiometric amounts of Ac2O in organic solvents; both methods require the addition of basic or acid catalysts to promote the esterification. Therefore, they usually lead to the generation of high amounts of wastes, which sensibly raise the E-factor of the process. With the aim to develop a more sustainable system, a solvent-free, stoichiometric acetylation protocol is, thus, proposed. The naturally occurring phenol, thymol, can be converted to the corresponding-biol. active-ester with good yields, in the presence of 1% of VOSO4. Interestingly, the process can be efficiently adopted to synthesize other thymyl esters, as well as to perform acetylation of alcs. and aryl and alkyl thiols. Remarkably, a further improvement has been achieved replacing Ac2O with its greener alternative, isopropenyl acetate (IPA).
Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Acetylation. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Formula: C9H10O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics