Oosthoek-de Vries, Anna Jo published the artcileInline Reaction Monitoring of Amine-Catalyzed Acetylation of Benzyl Alcohol Using a Microfluidic Stripline Nuclear Magnetic Resonance Setup, Recommanded Product: Benzyl acetate, the main research area is amine catalyzed acetylation benzyl alc microfluidic stripline NMR monitoring.
We present an in-depth study of the acetylation of benzyl alc. in the presence of N,N-diisopropylethylamine (DIPEA) by NMR monitoring of the reaction from 1.5 s to several minutes. We have adapted the NMR setup to be compatible to microreactor technol., scaling down the typical sample volume of com. NMR probes (500 μL) to a microfluidic stripline setup with 150 nL detection volume Inline spectra are obtained to monitor the kinetics and unravel the reaction mechanism of this industrially relevant reaction. The experiments are combined with conventional 2D NMR measurements to identify the reaction products. In addition, we replace DIPEA with triethylamine and pyridine to validate the reaction mechanism for different amine catalysts. In all three acetylation reactions, we find that the acetyl ammonium ion is a key intermediate. The formation of ketene is observed during the first minutes of the reaction when tertiary amines were present. The pyridine-catalyzed reaction proceeds via a different mechanism.
Journal of the American Chemical Society published new progress about Acetylation. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Recommanded Product: Benzyl acetate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics