Eddine, Naoures J. published the artcileIron (III) Chloride Hexahydrate as a Highly Efficient Catalyst for Acetylation of Protic Nucleophiles with Acetic Anhydride under Solvent-free Conditions, Safety of Benzyl acetate, the main research area is iron chloride hexahydrate catalyst acetylation protic nucleophile acetic anhydride; solvent free condition.
Acetylation of protic nucleophiles is used to protect these functional groups. Most of the methods described in the literature use solvents, one or more equivalent of toxic bases or expensive and toxic catalysts. Therefore, new methodologies, above all, greener and more economical procedures, are still in demand. An eco-efficient method was developed for the acetylation of alcs., phenols, thiols, amines, and carbohydrates, using acetic anhydride and a catalytic amount of the environmentally benign and inexpensive FeCl3.6H2O under solvent-free conditions. Acetylation of a variety of protic nucleophiles was performed using 0.2 mol % of FeCl3.6H2O as the catalyst, and 1.2 equiv of Ac2O as the acetylating agent at room temperature and under solvent-free conditions. This procedure appears to be highly efficient and promoted rapid and quant. acetylation under simple and min. manipulation. Chromatog. or recrystallization was generally not necessary for the purification of products. This eco-friendly protocol appears to be potentially universally applicable in organic design to protect protic nucleophiles and isscalable for industrial fields.
Current Organocatalysis published new progress about Acetylation. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Safety of Benzyl acetate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics