Mohammadi, Ghobad published the artcileChemical characterization and anti-breast cancer effects of silver nanoparticles using Phoenix dactylifera seed ethanolic extract on 7,12-Dimethylbenz[a] anthracene-induced mammary gland carcinogenesis in Sprague Dawley male rats, SDS of cas: 111-11-5, the main research area is breast cancer silver nanoparticle Phoenix seed extract antitumor.
The aim of the recent research was to investigate the anti-breast cancer effects of silver nanoparticles using Phoenix dactylifera seed ethanolic extract (AgNPs). After preparation of Phoenix dactylifera seed extract, GC/MS was performed to detect the compounds The findings indicated that 9-Octadecenoic acid (Z)- Me ester (40.95%) and Dodecanoic acid Me ester (20%) were the most frequent constituents found in P. dactylifera. These nanoparticles were spherical with a size range of 17-19 nm and characterized using various anal. techniques including UV-Vis absorption spectroscopy to determine the presence of AgNPs in the solution We studied functional groups of P. dactylifera extract in the reduction and capping process of AgNPs by FT-IR, crystallinity and FCC planes by X-ray diffraction (XRD) pattern and surface morphol., shapes, and size of AgNPs by SEM and transmission electron microscopy (TEM). DPPH free radical scavenging test was used to test the antioxidant properties of P. dactylifera and AgNPs, which revealed high antioxidant potential similar to butylated hydroxy toluene (BHT) as the pos. control. The results of cytotoxicity anal. indicated that P. dactylifera and AgNPs were toxic for MCF-7 cells. In vivo design, induction of breast cancer was done by 7,12-Dimethylbenz[a] anthracene (DMBA) in 50 animals. After 10 days, the animals were randomly divided into six subgroups, including healthy control, untreated control, two groups receiving the P. dactylifera at 2 and 6 mg/kg and two groups receiving the AgNPs at 2 and 6 mg/kg concentrations Both doses of P. dactylifera and AgNPs (especially AgNPs6) significantly (p â?0.05) reduced the weight and volume of liver, mammary gland, kidney, spleen, ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, urea, creatinine, glucose, ferrous, ferritin, erythropoietin, GR, IL1, IL6, IL12, IL18, IFNY, and TNFα and increased HDL, total protein, albumin, WBC, lymphocyte, neutrophils, platelet, RBC, Hb, PCV, MCV, MCH, MCHC, SOD, CAT, GPx, IL4, IL5, IL10, IL13, and IFNα compared to the untreated group. Moreover, P. dactylifera and AgNPs (especially AgNPs6) significantly (p â?0.05) treated breast cancer with reduction of organs free of metastasis compared to the untreated group. Seemingly, the AgNPs can be used for the treatment of breast cancer.
Applied Organometallic Chemistry published new progress about Antioxidants. 111-11-5 belongs to class esters-buliding-blocks, name is Methyl octanoate, and the molecular formula is C9H18O2, SDS of cas: 111-11-5.
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