Kolcsar, Vanessza Judit published the artcileSynthesis of a Pyrrolo[1,2-a]quinazoline-1,5-dione Derivative by Mechanochemical Double Cyclocondensation Cascade, Quality Control of 539-88-8, the main research area is methyl tetrahydropyrroloquinazoline dione preparation green chem; anthranilamide ethyl levulinate mechanochem double cyclocondensation cascade; Amberlyst® 15; Brønsted acid; anthranilamide; ball mill; cascade reaction; ethyl levulinate; mechanochemistry; quinazolinone.
N-heterocyclic compounds, such as quinazolinone derivatives, have significant biol. activities. Nowadays, as the demand for environmentally benign, sustainable processes increases, the application of compounds from renewable sources, easily separable heterogeneous catalysts and efficient, alternative activation methods is of great importance. In this study, a convenient, green procedure for the preparation of 3a-methyl-2,3,3a,4-tetrahydropyrrolo[1,2-a]quinazoline-1,5-dione through a double cyclocondensation cascade using anthranilamide and Et levulinate was developed. Screening of various heterogeneous Bronsted acid catalysts showed that Amberlyst 15 is a convenient choice. By applying mechanochem. activation in the preparation of this N-heterotricyclic compound for the first time, it was possible to shorten the necessary time to three hours compared to the 24 h needed under conventional conditions to obtain a high yield of the target product.
Molecules published new progress about Ball milling. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Quality Control of 539-88-8.
Referemce:
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