Wu, Hongguo published the artcileHot water-promoted catalyst-free reductive cycloamination of (bio-)keto acids with HCOONH4 toward cyclic amides, Recommanded Product: Ethyl 4-oxopentanoate, the main research area is keto acid ammonium formate tandem reductive cycloamination; cyclic amide preparation.
HCOONH4 was demonstrated to be capable of acting as both hydrogen and nitrogen source in the absence of any catalyst and additive for the reductive cycloamination of bio-based levulinic acid (LA) to 5-methyl-2-pyrrolidone (MPL) with more than 90% in just 60 min at 180°. Pressurized hot water remarkably enabled the reaction efficiency and rate by promoting the hydrolysis of HCOONH4 to liberated ammonia and formic acid for the cascade reactions and this catalyst-free protocol was also applicable to the efficient synthesis of various cyclic amides from relevant keto acids. Moreover, the reaction pathways were investigated by conducting deuterium-labeling experiments and kinetic studies of selected reactions.
Journal of Supercritical Fluids published new progress about Amidation kinetics. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Recommanded Product: Ethyl 4-oxopentanoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics