Tzou, Philip L. published the artcileCoronavirus antiviral research database (CoV-RDB): an online database designed to facilitate comparisons between candidate anti-coronavirus compounds, Recommanded Product: 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, the main research area is coronavirus antiviral database; COVID-19; MERS-CoV; SARS-CoV; SARS-CoV-2; antiviral therapy; coronavirus.
Background: To prioritize the development of antiviral compounds, it is necessary to compare their relative preclin. activity and clin. efficacy. Methods: We reviewed in vitro, animal model, and clin. studies of candidate anti-coronavirus compounds and placed extracted data in an online relational database. Results: As of August 2020, the Coronavirus Antiviral Research Database (CoV-RDB; covdb.stanford.edu) contained over 2800 cell culture, entry assay, and biochem. experiments, 259 animal model studies, and 73 clin. studies from over 400 published papers. SARS-CoV-2, SARS-CoV, and MERS-CoV account for 85% of the data. Approx. 75% of experiments involved compounds with known or likely mechanisms of action, including monoclonal antibodies and receptor binding inhibitors (21%), viral protease inhibitors (17%), miscellaneous host-acting inhibitors (10%), polymerase inhibitors (9%), interferons (7%), fusion inhibitors (5%), and host protease inhibitors (5%). Of 975 compounds with known or likely mechanism, 135 (14%) are licensed in the U.S. for other indications, 197 (20%) are licensed outside the U.S. or are in human trials, and 595 (61%) are pre-clin. investigational compounds Conclusion: CoV-RDB facilitates comparisons between different candidate antiviral compounds, thereby helping scientists, clin. investigators, public health officials, and funding agencies prioritize the most promising compounds and repurposed drugs for further development.
Viruses published new progress about Antiviral agents. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Recommanded Product: 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate.
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