Shrestha, Shyam Sharan published the artcilePhytochemical Investigations and In Vitro Bioactivity Screening on Melia azedarach L. Leaves Extract from Nepal, Synthetic Route of 110-42-9, the main research area is Melia leaf phytochem compound bioactivity; Melia azedarach; enzyme inhibitory assays; phytosterols; polyphenols; traditional Nepalese medicine.
Melia azedarach is a common tree used in the traditional medicine of Nepal. In this work, leaves were considered as source of bioactive constituents and composition of methanol extract was evaluated and compared with starting plant material. Flavonoid glycosides and limonoids were identified and quantified by HPLC-DAD-MSn approaches in dried leaves and methanolic extract, while HPLC-APCI-MSn and GC/MS anal. were used to study phytosterol and lipid compositions β-Sitosterol and rutin were the most abundant constituents. HPLC-APCI-MSn and HPLC-DAD-MSn anal. revealed high levels of phytosterols and flavonoids in methanolic extract accounting 9.6 and 7.5% on the dried weight, resp. On the other hand, HPLC/MSn data revealed that limonoid constituents were in minor amount in the extract <0.1%, compared with leaves (0.7%) indicating that degradation occurred during extraction or concentration procedures. The methanol extract was subjected to different bioassays, and antioxidant activity was evaluated. Limited inhibitory activity on acetyl and butyryl cholinesterase, as well as on amylase were detected. Moreover, tyrosinase inhibition was significant resulting in 131.57±0.51 mg kojic acid equivalent/g of dried methanol extract, suggesting possible use of this M. azedarach extract in skin hyperpigmentation conditions. Moderate cytotoxic activity, with IC50 of 26.4μg/mL was observed against human ovarian cancer cell lines (2008 cells). Our findings indicate that the Nepalese M. azedarach leaves can be considered as valuable starting material for the extraction of phenolics and phytosterols, yielding extracts with possible cosmetic and pharmaceutical applications. Chemistry & Biodiversity published new progress about Cell morphology. 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, Synthetic Route of 110-42-9.
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