Sampaio, Guilherme A. published the artcileHistopathologic evaluation of experimental murine neurocysticercosis after treatment with albendazole/nitazoxanide combination, Category: esters-buliding-blocks, the main research area is neurocysticercosis albendazole nitazoxanide brain; Albendazole; Taenia crassiceps; anthelminthic drugs; experimental neurocysticercosis; nitazoxanide; pathologic evaluation.
Neurocysticercosis (NCC) is most common helminthic brain infection related to epilepsy. Only albendazole (ABZ) and praziquantel are used in its treatment. The development of new therapeutics has been encouraged. Taenia crassiceps cysticerci intracranial infection is the exptl. model used in NCC studies. This study evaluated the histopathol. of the brains of BALB/c mice exptl. infected with T. crassiceps cysticerci after the treatment with the ABZ/nitazoxanide (NTZ) combination. Thirty days after the inoculation the mice received an oral single dose of the ABZ/NTZ combination (40 mg kg-1 each). The control groups were treated with: NaCl 0.9%; ABZ or NTZ. The histopathol. evaluation of the brains was performed 24 h after treatment. The ABZ treatment induced discrete mononuclear inflammatory infiltration, meningitis, gliosis, hyperemia and hippocampus compression; moderate ependimitis and edema. The NTZ treatment induced accentuated inflammatory infiltration, foamy macrophages, ependimitis, choroiditis, gliosis and hyperemia and moderate edema. The ABZ/NTZ combination treatment induced a significant decrease in the polymorphonuclear inflammatory infiltration, ependimitis, choroiditis, gliosis, hyperemia and ventriculomegaly in comparison with the other groups. The cysticerci showed destruction of the tegument not observed in other groups. The ABZ/NTZ combination is efficient as the parasite showed signs of destruction and lower damage to the host’s tissue.
Parasitology published new progress about Brain hippocampus. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Category: esters-buliding-blocks.
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