Rasheed, Hafiz Majid published the artcileChemical profiling and anti-breast cancer potential of hexane fraction of Sphaeranthus indicus flowers, Recommanded Product: Methyl docosanoate, the main research area is Sphaeranthus flower extract anticancer breast cancer.
The current study aimed to determine the phytochems. and anti-breast cancer potential of Sphaeranthus indicus. S. indicus flowers were extracted with methanol followed by fractionation using n-hexane. For the chem. composition of n-hexane fraction, qual. phytochem. and GC-MS anal. were performed. The anti-proliferative activity was measured by MTT assay, whereas, cytotoxic and proapoptotic effects in MCF-7 (breast cancer) cells were determined using propidium iodide, 4,6-diamidino-2-phenylindole, dichlorofluorescin diacetate, and JC-1 staining through fluorescent microscopy. The phytochem. anal. indicated presence of phytosterols, oils and resins in the nhexane fraction. GC-MS anal. showed that n-hexane fraction comprises of 11 compounds including Me esters of caprylic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid, stearic acid, oleic acid, elaidic acid, linoleic acid, linolenic acid and behanic acid. The tested fraction showed remarkable cytotoxic activity against breast cancer (MCF-7) cells while it was found less toxic towards non-cancerous (BHK-21) cells. Furthermore, morphol. assessment through fluorescent microscopy revealed cytotoxic and apoptotic effects by improved cell membrane permeability, increased reactive oxygen species level, compromised mitochondrial activity and condensation of chromatin network. Conclusion: The n-hexane fraction of S. indicus contains phytosterols, oils and fatty acid Me esters and produced apoptotic effect against breast cancer cells.
Tropical Journal of Pharmaceutical Research published new progress about Antitumor agents. 929-77-1 belongs to class esters-buliding-blocks, name is Methyl docosanoate, and the molecular formula is C23H46O2, Recommanded Product: Methyl docosanoate.
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