Palos, Isidro published the artcileEsters of quinoxaline-7-carboxylate-1,4-di-N-oxide as Trichomonas vaginalis triosephosphate isomerase inhibitors, HPLC of Formula: 55981-09-4, the main research area is Trichomonas vaginalis Esters quinoxaline carboxylate 4diNoxide triosephosphate isomerase inhibitor.
Trichomoniasis is a public health problem worldwide. Trichomoniasis treatment consists of the use of nitroimidazole derivatives; however, therapeutic ineffectiveness occurs in 5 to 20% of the cases. Therefore, it is essential to propose new pharmacol. agents against this disease. In this work, esters of quinoxaline-7-carboxylate-1,4-di-N-oxide (EQX-NO) were evaluated in in vitro assays as novel trichomonicidal agents. Addnl., an in vitro enzyme assay and mol. docking anal. against triosephosphate isomerase of Trichomonas vaginalis to confirm their mechanism of action were performed. Et (compound 12) and Pr (compound 37) esters of quinoxaline-7-carboxy-late-1,4-di-N-oxide derivatives showed trichomonicidal activity comparable to nitazoxanide, whereas five Me (compounds 5, 15, 19, 20 and 22), four iso-Pr (compounds 28, 29, 30 and 34), three Et (compounds 4, 13 and 23) and one npropyl (compound 35) ester derivatives displayed activity comparable to albendazole. Compounds 6 and 20 decreased 100% of the enzyme activity of recombinant protein triosephosphate isomerase.
Acta Pharmaceutica (Warsaw, Poland) published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, HPLC of Formula: 55981-09-4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics