Alghamdi, Saleh B. published the artcileAssessment of antioxidant, antimicrobial, cytotoxic activities and isolation of some chemical constituents from different extracts of Pergularia daemia, Quality Control of 929-77-1, the main research area is Pergularia extract antioxidant antimicrobial agent cytotoxicity.
Pergularia demia is a wild plant growing in Albaha region. This study aimed to investigate some chem. constituents of P. demia and their biol. activities. The aerial parts of P. demia were extracted with water and organic solvents (chloroform, Et acetate, butanol, methanol, and petroleum ether). The chem. constituents of the unsaponifiable and the fatty acid fractions were identified using GC-MS analyses. The Et acetate and n-butanol extracts were subjected to chromatog. techniques. Total phenolic and flavonoid contents in the extracts were determined using colorimetric assay. The antioxidant activity was determined using 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay. The antimicrobial activity was evaluated using the modified Kirby-Bauer disk-diffusion method while the cytotoxic activity was evaluated using HepG-2 and HCT-116 cancer cell lines. Chromatog. separation of the Et acetate and n-butanol extracts afforded five flavonoidal compounds; apigenin, chyrsoeriol, quercetin, vitexin and lucenin-2.The total phenolic content of the extract ranged from 15.14 ± 0.02 to 39.33 ± 0.17 mg GAE/g. The Et acetate extract had the highest total flavonoid content (76.11 ± 0.16 mg QE/g) and the highest antioxidant activity (93.95%). The extracts showed varied degrees of inhibition against tested strains with the Et acetate extract having the maximum inhibition zone (17 to 23 mm against Staphylococcus aureus and Bacillus subtilis). The Et acetate extract showed a strong cytotoxicity activity against HEPG2 and HCT-116 cancer cell lines with IC50 values of 1.62 μg/mL and 2.48 μg/mL, resp. This is the first report of the isolation of the five flavonoidal compounds from P. demia. The plant has potential as antioxidant, antibacterial, and cytotoxic agents.
Tropical Journal of Natural Product Research published new progress about Aglycons Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 929-77-1 belongs to class esters-buliding-blocks, name is Methyl docosanoate, and the molecular formula is C23H46O2, Quality Control of 929-77-1.
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