Yang, Weiwei published the artcileMechanisms dissection of the combination GRS derived from ShengMai preparations for the treatment of myocardial ischemia/reperfusion injury, Quality Control of 2044-85-1, the main research area is ginsenoside ruscogenin schisandrin combination ShengMai myocardial ischemia reperfusion injury; 23915); 441893); 441922); Ajor chemical compounds studied in this article; Anti-inflammation; Antioxidation; Energy modulation; Ginsenoside Rb1 (PubChem CID; Multiple pathways; Myocardial ischemia/reperfusion injury; Ruscogenin (PubChem CID; Schisandrol a (PubChem CID; Shengmai combination GRS.
Recently, a new drug combination GRS comprising ginsenoside Rb1 (G-Rb1), ruscogenin (R-Rus) and schisandrin (S-SA) was screened based on ShengMai preparations, which exhibited a prominent cardioprotective effects against myocardial ischemia/reperfusion (MI/R) injury. To investigate their systemic and individual mechanism of each compound in combination GRS. The mice model of MI/R and hypoxia/reoxygenation (H/R)-induced cardiomyocytes injury were performed to explore the resp. characteristics of each compound in GRS against myocardial injury. Each component in the combination GRS attenuated MI/R injury as evidenced by decreased myocardial infarct size, ameliorated histol. features, and improved biochem. indicators. Meanwhile, ingredient G, R and S in combination also individually performed a significant decrease of apoptotic index in MI/R mice and H/R-induced cardiomyocytes injury. Mechanistically, component G in GRS could markedly increase the ATP content in cardiomyocytes through activation of AMPKα phosphorylation. Interestingly, the anti-apoptotic actions of G were profoundly attenuated by knockdown of AMPKα, while no alteration was observed on composition R and S. Moreover, component R in GRS significantly reduced the IL-6 and TNF-α mRNA expression, as well as the content of IL-6 via the modulation of NF-κB signaling pathway. Further, component S exhibited the most powerful anti-oxidative capacity in GRS and remarkably decreased the production of MDA and ROS, and potential mechanisms might at least in part through activating the Akt-14-3-3 signaling pathway and inhibiting the phosphorylation of Bad and ERK1/2. Our results indicated that the resp. mechanism of each compound in combination GRS against MI/R injury might closely associated with energy metabolism modulation, suppression of inflammation and oxidative stress.
Journal of Ethnopharmacology published new progress about 14-3-3 Proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Quality Control of 2044-85-1.
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