Ceccoli, Romina D. published the artcileGenome mining reveals new bacterial type I Baeyer-Villiger monooxygenases with (bio)synthetic potential, Application In Synthesis of 140-11-4, the main research area is genome mining type I Baeyer Villiger monooxygenase Bradyrhizobium; ketone oxidation lactone production Baeyer Villiger monooxygenase Bradyrhizobium.
Baeyer-Villiger monooxygenases (BVMOs) are oxidoreductases that catalyze the oxidation of ketones in a very selective manner. By genome mining we detected seven putative type I BVMOs in Bradyrhizobium diazoefficiens USDA 110. As we established the phylogenetic relationships among them and with other type I BVMOs, we found out that they belong to different clades of the phylogenetic tree. Thus, we decided to clone and heterologously express five of them. Three of them, each one from a divergent phylogenetic group, were obtained as soluble proteins, allowing us to proceed with their biocatalytic assessment and enzymic characterization. As to substrate scope and selectivity, we observed a complementary behavior among the three BVMOs. BVMO2 was the more versatile biocatalyst in whole-cell systems while BVMO4 and BVMO5 showed a narrow substrate profile with preference for linear ketones and particular regioselectivity for (±)-cis-bicyclo[3.2.0]hept-2-en-6-one.
Molecular Catalysis published new progress about Baeyer-Villiger oxidation. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Application In Synthesis of 140-11-4.
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