Improved one-pot synthesis of Acetylsalol, Benorilate, and Guacetisal. Prodrugs of aspirin was written by Wang, Zhi-zhong;Ma, Jiang-Yuan. And the article was included in Journal of Chemical and Pharmaceutical Research in 2012.Formula: C17H15NO5 The following contents are mentioned in the article:
Improved, cost-effective and one-pot methods for the synthesis of three aspirin prodrugs (Acetylsalol, Benorilate, Guacetisal) were achieved by using N,N’-carbonyldiimidazole as a coupling reagent. Moreover, the byproduct imidazole as the catalyst promoted the reactions. The procedures are simple and suitable to large-scale manufactures This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Formula: C17H15NO5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Formula: C17H15NO5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics