Effects of phenacetin, paracetamol, and caffeine on the erosive activity of acetylsalicyclic acid in the rat stomach: dose-response relationships, time course of erosion development, and effects on acid secretion was written by Seegers, A. J. M.;Jager, L. P.;Van Noordwijk, J.. And the article was included in Journal of Pharmacy and Pharmacology in 1979.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:
Adult male and female rats were equally susceptible to acetylsalicylic acid (I) [50-78-2]-induced gastric injury. Simultaneous administration of caffeine [58-08-2] or paracetamol (II) [103-90-2] resp. increased or decreased the degree of gastric lesion; phenacetin [62-44-2] administration had no effect. The effects of caffeine and II were dose-dependent and developed after 3-4 h. II or phenacetin pretreatment 1 h before I administration was ineffective. Benorylate [5003-48-5] administration caused no more erosions than equivalent mixtures of I and II. Histamine-stimulated gastric acid output was rapidly diminished during perfusion with I; II and caffeine had no initial effect on this but after 30 min the latter increased secretion to levels observed with caffeine alone. Thus, caffeine potentiates I-induced gastric erosions by stimulating acid secretion, but II inhibits them by preventing their development. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics