Synthesis and evaluation of the pharmacological activity of open analogues of cromakalim carrying urea and thiourea moieties was written by Mechouche, N.;Bouhedja, M.;Habila, T.;Stiti, MZ.;Faury, G.;Pirotte, B.;Khelili, S.. And the article was included in International Journal of Research in Pharmacy and Chemistry in 2022.Recommanded Product: 2253-73-8 The following contents are mentioned in the article:
Some new ring-opened analogs of cromakalim I [R1 = Me, Et, Bn; R2 = H, Me; R3 = i-Pr, t-Bu, Ph, etc.; X = H, OMe, Br; Y = O, S] bearing urea and thiourea moieties were synthesized and tested as vasodilators rat trachea and aorta of resp., and as stimulators of elastin synthesis from isolated humain vascular smooth muscle cells. Cromakalim, pinacidil, diazoxide, and verapamil were used as refrences compounds in the vasodilating experiments while diazoxide was used as a reference in the elastin experiments Furthur investigations were undertaken to determine the mechanism of action of the vasodilator activity. The pharmacol. results on rat aorta rings revealed that the most active vasodilator compound was I [R1 = Et, R2 = Me, R3 = 4-CNC6H5, X = Br, Y = S] and was almost 15-fold more active than diazoxide, but was 4-fold and 11 folds less active than pinacidil and cromakalim resp. FInvestigations on elastin synthesis showed that diazoxide significantly elevated elastin quantity by 34%. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Recommanded Product: 2253-73-8).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 2253-73-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics