Synthesis and evaluation of the pharmacological activity of open analogues of cromakalim carrying urea and thiourea moieties was written by Mechouche, N.;Bouhedja, M.;Habila, T.;Stiti, MZ.;Faury, G.;Pirotte, B.;Khelili, S.. And the article was included in International Journal of Research in Pharmacy and Chemistry in 2022.Product Details of 2253-73-8 The following contents are mentioned in the article:
Some new ring-opened analogs of cromakalim I [R1 = Me, Et, Bn; R2 = H, Me; R3 = i-Pr, t-Bu, Ph, etc.; X = H, OMe, Br; Y = O, S] bearing urea and thiourea moieties were synthesized and tested as vasodilators rat trachea and aorta of resp., and as stimulators of elastin synthesis from isolated humain vascular smooth muscle cells. Cromakalim, pinacidil, diazoxide, and verapamil were used as refrences compounds in the vasodilating experiments while diazoxide was used as a reference in the elastin experiments Furthur investigations were undertaken to determine the mechanism of action of the vasodilator activity. The pharmacol. results on rat aorta rings revealed that the most active vasodilator compound was I [R1 = Et, R2 = Me, R3 = 4-CNC6H5, X = Br, Y = S] and was almost 15-fold more active than diazoxide, but was 4-fold and 11 folds less active than pinacidil and cromakalim resp. FInvestigations on elastin synthesis showed that diazoxide significantly elevated elastin quantity by 34%. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Product Details of 2253-73-8).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 2253-73-8
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics