Lion, Claude published the artcileSynthesis of hindered acid chlorides. Study of their condensation with Grignard reagents in the presence of copper salts. Preparation of highly branched ketones, Recommanded Product: Ethyltert-butylacetate, the publication is Journal of Chemical Research, Synopses (1978), 46, database is CAplus.
Sequential treatment of RCH2CO2R1 (I; R = iso-Pr, R1 = H) with R2X (R2 = Me, Et, X = halide), SOCl2, and EtOH gave 97-8% RCHR2CO2Et (II). Similar alkylation of I (R = Me3C, R1 = Et) gave 92-6% II (R = Me3C, R2 = Me, Et). Further alkylation of the esters II (R = iso-Pr, Me3C, R2 = Me, Et) with R3X (R3 = iso-Pr, Et, X = halide) gave 32-81% RCR2R3CO2Et, which on saponification gave 78-91% RCR2R3CO2H (III). Treatment of III (R = iso-Pr, Me3C, R2 = Me, Et, R3 = iso-Pr; R = Me3C, R2 = R3 = Et) with SOCl2 gave the corresponding acid chlorides which reacted with R4MgX (R4 = Me, X = I; R = neopentyl, Me3C, X = Cl) in presence of CuCl to give 39-93% RCR2R3COR4.
Journal of Chemical Research, Synopses published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Recommanded Product: Ethyltert-butylacetate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
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