Novel thiosemicarbazone derivatives containing benzimidazole moiety: Green synthesis and anti-malarial activity was written by Divatia, Saavani M.;Rajani, Dhanji P.;Rajani, Smita D.;Patel, Hitesh D.. And the article was included in Arabian Journal of Chemistry in 2019.Computed Properties of C4H7NS The following contents are mentioned in the article:
A series of (E)-2-[5-chloro-1-(1H-benzo[d]imidazol-2-yl)ethylidene]-N-(substituted)hydrazine carbothioamides and (E)-2-[1-(1H-benzo[d]imidazol-2-yl)ethylidene]-N-(substituted)hydrazine carbothioamides I (X = H, Cl; R = H, Ph, Et, etc.) were prepared via the synthesis of 1-(substituted-1H-benzimidazol-2-yl)ethanol which was synthesized by the condensation of substituted o-phenylenediamine with DL-lactic acid followed by oxidation with sodium hypochlorite in mild acidic condition to form the corresponding ketones. Final compounds were formed by condensation of corresponding ketones with different thiosemicarbazides. A total of 40 compounds were synthesized and evaluated for anti-malarial properties. Among the compounds tested I (X = Cl, H; R = OCC6H5, 4-FC6H4, 4-IC6H4, 4-MeC6H4, 2,3-Cl2C6H3, 3,4-ClC6H3, c-C6H11, 4-MeOC6H4) exhibited good antimalarial activity in vitro. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Computed Properties of C4H7NS).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Computed Properties of C4H7NS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics