Novel thiosemicarbazone derivatives containing benzimidazole moiety: Green synthesis and anti-malarial activity was written by Divatia, Saavani M.;Rajani, Dhanji P.;Rajani, Smita D.;Patel, Hitesh D.. And the article was included in Arabian Journal of Chemistry in 2019.Category: esters-buliding-blocks The following contents are mentioned in the article:
A series of (E)-2-[5-chloro-1-(1H-benzo[d]imidazol-2-yl)ethylidene]-N-(substituted)hydrazine carbothioamides and (E)-2-[1-(1H-benzo[d]imidazol-2-yl)ethylidene]-N-(substituted)hydrazine carbothioamides I (X = H, Cl; R = H, Ph, Et, etc.) were prepared via the synthesis of 1-(substituted-1H-benzimidazol-2-yl)ethanol which was synthesized by the condensation of substituted o-phenylenediamine with DL-lactic acid followed by oxidation with sodium hypochlorite in mild acidic condition to form the corresponding ketones. Final compounds were formed by condensation of corresponding ketones with different thiosemicarbazides. A total of 40 compounds were synthesized and evaluated for anti-malarial properties. Among the compounds tested I (X = Cl, H; R = OCC6H5, 4-FC6H4, 4-IC6H4, 4-MeC6H4, 2,3-Cl2C6H3, 3,4-ClC6H3, c-C6H11, 4-MeOC6H4) exhibited good antimalarial activity in vitro. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Category: esters-buliding-blocks).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics