Chu, Yeonjeong et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2020 | CAS: 2253-73-8

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 2253-73-8

Design, synthesis, and biological evaluation of N-arylpiperazine derivatives as interferon inducers was written by Chu, Yeonjeong;Raja Sekhara Reddy, B.;Pratap Reddy Gajulapalli, V.;Sudhakar Babu, K.;Kim, Eunha;Lee, Sanghee. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.SDS of cas: 2253-73-8 The following contents are mentioned in the article:

Type I Interferon (IFN) signaling plays an important role in the immune defense system against virus infection and in the innate immune response, thus IFNs are widely used as anti-viral agents and treatment for immune disorder or cancer. However, there is a growing demand for novel small-mol. IFN inducer due to tolerance, toxicity, or short duration of action following direct administration of IFNs. The authors assessed arylpiperazine (ARP) as a new core skeleton of IFN inducer. To study structure-activity relation, the authors designed and synthesized a series of ARP analogs and evaluated the ability to stimulate IFN response in THP-1 human monocyte cells. Compound 1-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-(3,4,5-trimethoxyphenyl)ethenone was identified as a potent type I IFN inducer as it significantly increased cytokine secretion and increased expression of various IFN-stimulating genes which are representative biomarkers of type I IFN pathway. The authors’ results suggested a beneficial therapeutic potential of 1-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-(3,4,5-trimethoxyphenyl)ethenone as an anti-viral agent. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8SDS of cas: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics