Chiummiento, Lucia published the artcileNew indolic non-peptidic HIV protease inhibitors from (S)-glycidol: synthesis and preliminary biological activity, Safety of (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, the publication is Tetrahedron (2009), 65(31), 5984-5989, database is CAplus.
A series of non-peptidic HIV protease inhibitors, e.g., I, were synthesized starting from the same optically active precursor, (S)-glycidol. The substrate was easily converted into different indolic sulfonamides or amines by regioselective reactions. The preliminary inhibitory activity was evaluated.
Tetrahedron published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Safety of (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate.
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