Cecchetti, Violetta published the artcilePotent 6-defluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy, Application of Ethyl 3-(dimethylamino)acrylate, the publication is Journal of Medicinal Chemistry (1996), 39(25), 4952-4957, database is CAplus and MEDLINE.
In a furtherance of our SAR study on the C-6 position of quinolone antibacterials, a series of 6-defluoro-8-methylquinolones were synthesized and evaluated for their in vitro antimicrobial activity. As a result of this study, compounds with strong activity against Gram-pos. bacteria, including ciprofloxacin-resistant and methicillin-resistant Staphylococcus aureus, were identified. The best Gram-pos. antibacterial activity was exhibited by piperidinyl derivative which was 17 times more potent than ciprofloxacin and displayed extremely high activity against Streptococcus pneumoniae with an MIC value of ≤0.016 μg/mL. Thus, we have shown that substituent combinations in the quinolone ring, excluding the C-6 fluorine atom, might produce powerful antibacterial agents.
Journal of Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Application of Ethyl 3-(dimethylamino)acrylate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics