Ag(I)-Catalyzed rapid access to 2-amino-4-methylenethiazolines with potential applications in bioconjugation chemistry was written by Xiang, Lingling;Wu, Haiting;Liang, Yunshi;Deng, Huiying;He, Yiting;Xu, Qin;Zhang, Jing. And the article was included in Organic & Biomolecular Chemistry in 2021.COA of Formula: C4H7NS The following contents are mentioned in the article:
An Ag(I)-catalyzed tandem addition-cyclization of isothiocyanate RNCS (R = Ph, cyclohexyl, i-Pr, etc.) and propargylamine was successfully applied to the synthesis of 2-amino-4-methylenethiazolines I. This route features an unprecedented fast reaction rate with full conversion reached within 10 min at room temperature for aromatic isothiocyanates and excellent chemoselectivity for exocyclic products. The application of this strategy is further highlighted by the accelerated bioconjugation of propargylamine with fluorescein isothiocyanate (FITC) under Ag(I)-catalysis. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8COA of Formula: C4H7NS).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.COA of Formula: C4H7NS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics