Synthesis and biological evaluation of Isosteviol derivatives as FXa inhibitors was written by Shi, Yang;Pan, Bo-Wen;Li, Wen-Chao;Wang, Qing;Wu, Qiong;Pan, Meng;Fu, Hong-Zheng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Synthetic Route of C4H7NS The following contents are mentioned in the article:
Firstly, a series of Isosteviol derivatives were synthesized and evaluated for FXa inhibitory activity. Among these compounds, the inhibitory activity of three compounds on FXa was better than that of Isosteviol. Secondly, surface plasmon resonance (SPR) assays were performed for selected compounds The three compounds have similar kinetic signatures, and affinity values were at μM level. Thirdly, two compounds displayed moderate-to-high anticoagulation activity and showed similar sensitivity to PT and aPTT. These findings will provide new insight into the exploration of FXa inhibition. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Synthetic Route of C4H7NS).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C4H7NS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics