Synthesis and biological evaluation of Isosteviol derivatives as FXa inhibitors was written by Shi, Yang;Pan, Bo-Wen;Li, Wen-Chao;Wang, Qing;Wu, Qiong;Pan, Meng;Fu, Hong-Zheng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.HPLC of Formula: 2253-73-8 The following contents are mentioned in the article:
Firstly, a series of Isosteviol derivatives were synthesized and evaluated for FXa inhibitory activity. Among these compounds, the inhibitory activity of three compounds on FXa was better than that of Isosteviol. Secondly, surface plasmon resonance (SPR) assays were performed for selected compounds The three compounds have similar kinetic signatures, and affinity values were at μM level. Thirdly, two compounds displayed moderate-to-high anticoagulation activity and showed similar sensitivity to PT and aPTT. These findings will provide new insight into the exploration of FXa inhibition. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8HPLC of Formula: 2253-73-8).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 2253-73-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics