One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles was written by Savych, Olena;Kuchkovska, Yuliya O.;Bogolyubsky, Andrey V.;Konovets, Anzhelika I.;Gubina, Kateryna E.;Pipko, Sergey E.;Zhemera, Anton V.;Grishchenko, Alexander V.;Khomenko, Dmytro N.;Brovarets, Volodymyr S.;Doroschuk, Roman;Moroz, Yurii S.;Grygorenko, Oleksandr O.. And the article was included in ACS Combinatorial Science in 2019.Category: esters-buliding-blocks The following contents are mentioned in the article:
Two protocols for the combinatorial synthesis of 5-(dialkylamino)tetrazoles were developed. The best success rate (67%) was shown by the method that used primary and secondary amines, 2,2,2-trifluoroethylthiocarbamate, and sodium azide as the starting reagents. The key steps included the formation of unsym. thiourea, subsequent alkylation with 1,3-propane sultone and cyclization with azide anion. A 559-member aminotetrazole library was synthesized by this approach; the overall readily accessible (REAL) chem. space covered by the method exceeded 7 million feasible compounds This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Category: esters-buliding-blocks).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics