Structure-activity relationships in antiinflammatory drugs and predictability was written by Mager, Peter P.;Metzner, J.;Paintz, M.;Wenzel, U.. And the article was included in Scientia Pharmaceutica in 1980.Formula: C17H15NO5 The following contents are mentioned in the article:
The antiinflammatory activity of salicylic acid and pyrazolone derivatives was regressed against Hammett’s electronic constant, Hansch’s lipophilic substitution constant, and Mager’s relative surface tension. There is a sufficient recognition (comparison between exptl. obtained and theor. calculated values) and predictability (comparison between forecasts and exptl. proof after synthesis). This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Formula: C17H15NO5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C17H15NO5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics