Benorylate hydrolysis by human plasma and human liver was written by Williams, Faith M.;Moore, U.;Seymour, R. A.;Mutch, E. M.;Nicholson, E.;Wright, P.;Wynne, H.;Plain, P. G.;Rawlins, M. D.. And the article was included in British Journal of Clinical Pharmacology in 1989.Recommanded Product: 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:
Benorylate (4-acetamido phenyl-O-acetylsalicylate) (I) hydrolysis in vitro by human plasma and by human liver microsomes an cytosol has been investigated. Benorylate was hydrolyzed by a route involving initial hydrolysis of the acetyl group to yield phenetsal followed by hydrolysis to paracetamol and salicylate. Hydrolysis via acetylsalicylate was minor. Benorylate was more actively hydrolyzed by liver cytosol than microsomes and about 10 times faster than plasma. Following a single oral dose benorylate (4 g) to volunteers only salicylate and paracetamol were detected in the plasma. The therapeutic effects of benorylate appear to be mediated by salicylate and paracetamol. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Recommanded Product: 4-Acetamidophenyl 2-acetoxybenzoate).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: 4-Acetamidophenyl 2-acetoxybenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics