Olefin-Oriented Selective Synthesis of Linear and Branched N-Alkylated Heterocycles by Hydroamination was written by Sushmita;Aggarwal, Trapti;Saini, Kapil Mohan;Verma, Akhilesh K.. And the article was included in European Journal of Organic Chemistry in 2020.Formula: C4H7NS The following contents are mentioned in the article:
An effective base-induced selective approach for the synthesis of linear and branched N-alkylated heterocycles by hydroamination of olefins has been described. The designed C-N bond formation method was directed through the olefin, as with styrenes only linear N-alkylated product was obtained, and acrylates gave linear as well as branched alkylated heterocycles. This protocol provided the synthesis of exclusive N-alkylated product instead of the C-3 Michael addition product. The reaction was also compatible with Ph vinyl sulfone, thus leading to the formation of sulfone substituted heterocycles in good yield. Further, the method was utilized for the synthesis of medicinally important analogs of CB1 Cannabinoid receptor and Dimebon analog in short reaction sequence. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C4H7NS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics