Synthesis and pharmacological properties of eterylate, a new derivative of acetylsalicylic acid was written by Sunkel, C.;Cillero, F.;Armijo, M.;Pina, M.;Alonso, S.. And the article was included in Arzneimittel-Forschung in 1978.Recommanded Product: 5003-48-5 The following contents are mentioned in the article:
Eterylate (I) [62992-61-4] was prepared by coupling p-(2-hydroxyethoxy)acetanilide [50375-15-0] with o-acetoxybenzoyl chloride [5538-51-2] and tested for antiinflammatory and analgesic activities. The activities of I were similar to those of acetylsalicylic acid and benorylate in equimol. doses. The oral LD50 in mice for I, benorylate, and acetylsalicylic acid, were 3160, 1551, and 1259 mg/kg, resp. The gastrointestinal lesions observed after treatment for 30 days revealed that both I and benorylate were tolerated better than acetylsalicylic acid. Further, I had the advantage of causing less gastric lesioning and less hemorrhaging. Phys. and chem. properties of I are discussed. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Recommanded Product: 5003-48-5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 5003-48-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics