Synthesis and anxiolytic activity of some novel benzotriazole derivatives was written by Singh, V. K.;Bharadwaj, Peeyush;Rishishwar, Poonam. And the article was included in Journal of Drug Delivery and Therapeutics in 2019.Recommanded Product: 2253-73-8 The following contents are mentioned in the article:
1,2,3-Benzotriazole (BTA) is a heterocyclic compound with three nitrogen atoms. It is a polar and colorless compound which can be used for its great versatility. The enormous investigations on derivatives of benzotriazole reveal wide applicability for tagging and delivering a number of heterocyclic nuclei with this mol. In the present work synthesis of several derivatives of 1-(substituted)-5-[(N-benzotriazolomethyl)-1,3, 4-thiadiazolyl]- imidazole-2-thione has been synthesized and are evaluated for their anxiolytic activity. The antianxiety activities of the synthesized derivatives were evaluated using EPM test and Bright and dark box test exptl. models of anxiety. All results were expressed as mean± standard error mean (SEM) and analyzed by one-way ANOVA. Post-hoc comparisons were performed by applying Dunnet′s test. P <0.05 was considered statistically significant. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Recommanded Product: 2253-73-8).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 2253-73-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics