Sato, Motohide published the artcileQuinolone Carboxylic Acids as a Novel Monoketo Acid Class of Human Immunodeficiency Virus Type 1 Integrase Inhibitors, SDS of cas: 924-99-2, the publication is Journal of Medicinal Chemistry (2009), 52(15), 4869-4882, database is CAplus and MEDLINE.
The synthesis and detailed structure-activity relationship of quinolonecarboxylic acids as a novel monoketo acid class of HIV-1 integrase inhibitors was presented. Compounds I (R = t-Bu), which showed an IC50 of 5.8 nM in the strand transfer assay and an ED50 of 0.6 nM in the antiviral assay, and I (R = i-Pr), which had an IC50 of 7.2 nM and an ED50 of 0.9 nM, were the most potent compounds in this class. The monoketo acid I (R = i-Pr) was much more potent at inhibiting integrase-catalyzed strand transfer processes than 3′-processing reactions, as is the case with the keto-enol acids. Elvitegravir I (R = i-Pr) was chosen as a candidate for further studies and was reported as being in phase 3 clin. trials.
Journal of Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, SDS of cas: 924-99-2.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics