The comparative gastric ulcerogenic activities of nonsteroid antiinflammatory drugs was written by Rainsford, K. D.. And the article was included in Agents and Actions in 1977.Synthetic Route of C17H15NO5 The following contents are mentioned in the article:
A new gastric assay was employed to screen for the ulcerogenic activity of non-steroid antiinflammatory (NSAI) analgesics. The technique involves exposing rats to brief periods of cold stress, which is not itself sufficient to cause mucosal damage, but does specifically sensitize the stomach to irritant or ulcerogenic actions of NSAI drugs. The assessment of gastric ulcerogenicity of some well-known antiinflammatory/analgesic drugs using this new assay was shown to agree well with clin. reports of the occurrence of gastric ulceration and hemorrhage. This assay was employed to screen for the ulcerogenicity of some new antiinflammatory drugs and for potential drug interactions resulting from administration of certain frequently used combinations of these drugs. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Synthetic Route of C17H15NO5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C17H15NO5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics