Miyauchi, Rie published the artcileDesign, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria, Quality Control of 924-99-2, the publication is Bioorganic & Medicinal Chemistry (2009), 17(19), 6879-6889, database is CAplus and MEDLINE.
A series of novel 6-desfluoro [des-F(6)] and 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methoxyquinolones bearing 3-(1-aminocycloalkyl)pyrrolidin-1-yl substituents at the C-7 position (1-6) was synthesized to obtain potent drugs for nosocomial infections caused by Gram-pos. pathogens. The des-F(6) compounds 4-6 exhibited at least four times more potent activity against representative Gram-pos. bacteria than ciprofloxacin or moxifloxacin. Among the derivatives, 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] derivative 4, which showed favorable profiles in preliminary toxicol. and non-clin. pharmacokinetic studies, exhibited potent antibacterial activity against clin. isolated Gram-pos. pathogens that had become resistant to one or more antibiotics.
Bioorganic & Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Quality Control of 924-99-2.
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https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics