Marquis, Robert W. published the artcileAntagonists of the Calcium Receptor I. Amino Alcohol-Based Parathyroid Hormone Secretagogues, Computed Properties of 115314-17-5, the publication is Journal of Medicinal Chemistry (2009), 52(13), 3982-3993, database is CAplus and MEDLINE.
Functional screening of the former SmithKline Beecham compound collection against the human calcium receptor (CaR) resulted in the identification of the amino alc.-based hit 2 (IC50 = 11 μM). Structure-activity studies of 2 focused on the optimization of the right- and left-hand side aromatic moieties as well as the amino alc. linker region. Critical to the optimization of this antagonist template was the discovery that the chirality of the C-2 secondary alc. played a key role in enhancing both CaR potency as well as selectivity over the β-adrenergic receptor subtypes. These SAR studies ultimately led to the identification of 38 (NPS 2143; SB-262470A), a potent and orally active CaR antagonist. Pharmacokinetic characterization of 38 in the rat revealed that this mol. had a large volume of distribution (11 L/kg), which resulted in a prolonged systemic exposure, protracted increases in the plasma levels of PTH, and an overall lack of net bone formation effect in a rodent model of osteoporosis.
Journal of Medicinal Chemistry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Computed Properties of 115314-17-5.
Referemce:
https://en.wikipedia.org/wiki/Ester,
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