Design, Synthesis, and Biological Activity of β-Carboline Analogues Containing Hydantoin, Thiohydantoin, and Urea Moieties was written by Huang, Yuanqiong;Guo, Zhonglin;Song, Hongjian;Liu, Yuxiu;Wang, Lizhong;Wang, Qingmin. And the article was included in Journal of Agricultural and Food Chemistry in 2018.Electric Literature of C4H7NS The following contents are mentioned in the article:
A series of novel β-carboline derivatives was designed by combining the anti-tobacco mosaic virus (TMV) lead compound tetrahydro-β-carboline ester with the hydantoin, thiohydantoin, and urea motifs. These derivatives were synthesized from tetrahydro-β-carboline ester via a structural diversity-oriented synthesis in one step, and their biol. activities were evaluated. Most of the derivatives exhibited anti-TMV activity higher than that of com. plant virucide ribavirin. Compared with the lead compounds, some of these derivatives showed good insecticidal activity against Plutella xylostella and Culex pipiens pallens. At the same time, these derivatives also showed broad-spectrum fungicidal activity. The systematic study provides strong evidence that the hydantoin, thiohydantoin, and urea motifs of these mols. can improve and modulate the activities of the analogs of natural products. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Electric Literature of C4H7NS).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Electric Literature of C4H7NS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics