Demkowicz, Sebastian published the artcilePhosphate and Thiophosphate Biphenyl Analogs as Steroid Sulfatase Inhibitors, Category: esters-buliding-blocks, the publication is Drug Development Research (2015), 76(2), 94-104, database is CAplus and MEDLINE.
Preclin. Research In the present work, we report convenient methods for the synthesis and biol. evaluation of phosphate and thiophosphate biphenyl derivatives exhibiting steroid sulfatase (STS) activity. The described synthesis is based on straightforward preparation of biphenyl-4-ol and 4′-hydroxy-biphenyl-4-carboxylic acid Et ester modified with various phosphate or thiophosphate moieties. The inhibitory effects of these compounds were tested on STS isolated from human placenta and led to two compounds of interest, 5a and 5d with IC50 values of 28.0 and 22.1 μM, resp. and that had interesting new binding modes in the STS active site. Drug Dev Res, 2015. © 2015 Wiley Periodicals, Inc.
Drug Development Research published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Category: esters-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Ester,
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