Evaluation of benorylate and its active metabolites by HPLC and comparative bioavailability investigation in human plasma was written by Chen, Jun;Tu, Xide;Gao, Jie. And the article was included in Zhongguo Yaoke Daxue Xuebao in 1995.Formula: C17H15NO5 The following contents are mentioned in the article:
An anal. method of HPLC was developed which detected benorylate and its active metabolites in order to compare the bioavailability in human plasma. Extraction from plasma was carried out in two steps with ether and acetate. The separation was performed on the YWG C18 column with mobile phase of methanol-pH 2.1 phosphate buffer (60:50) at 238 nm of detection wavelength. The lowest limit was 50 ng for paracetamol and salicylic acid. The mean recoveries in plasma were 97.57 ± 6.15%, 97.43 ± 4.39% for SA and PA resp. The plasma concentration of 8 healthy volunteers after taking benorylate tablet A (500 mg × 9) and B (400 mg × 9) was detected. The results showed that the maximum plasma concentration of SA was 113.05 μg/mL from tablet A and 131.78 μg/mL from B; the top time was 2.5 and 2.0 h for A and B resp. The relative bioavailability of B to A was 125.59%. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Formula: C17H15NO5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C17H15NO5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics